Student Work

Design of a Tissue Ring Contractile Force Measurement Device

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A potential application for tissue engineering is the development of functional, three-dimensional vascular constructs to aid in drug discovery. The goal of the project was to create a device that measures the contractile force of vascular ring constructs in response to chemical stimulation to model blood vessel function in vitro. A polydimethylsiloxane (PDMS) device consisting of a well and a center base with four extruding microposts was developed. Tissue rings were mounted on the posts and exposed to saline solution with or without potassium. Potassium-mediated smooth muscle contraction caused micropost deflection, which was measured with a stereomicroscope and used to calculate force. This presents a method to quantify the contraction response of tissue ring constructs.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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Publisher
Identifier
  • E-project-042512-083935
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Year
  • 2012
Date created
  • 2012-04-25
Resource type
Major
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Ultima modifica
  • 2021-02-02

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