Spring-Loaded Needle Delivery System of Cells into Decellularized Scaffold

Domkofski, Cosette; Kieu, Minh Anh; Sundaraneedi, Siri; Baker, Lexi

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Spring-Loaded Needle Delivery System of Cells into Decellularized Scaffold

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Large volume tissue injuries, such as those in burn victims or myocardial infarction, have proven difficult to treat given the amount of tissue that must be replaced. One of the most promising forms of treatment is using a decellularized scaffold for the repopulation of autologous cells. Our approach shows proof of concept for the recellularization of thick scaffolds as for use in vivo. This project includes the development of a standardized decellularization procedure to create a scaffold out of a large volume tissue, the design of a microneedle device to seed cells onto a scaffold and verifies seeding and scaffold biocompatibility. Once developed further, this novel way of seeding cells onto large volume tissues could have major applications in wound healing.

This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

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