PDT is an emerging cancer treatment that combines both light and a photosensitizing agent to produce reactive oxygen in cells. Although upconversion nanoparticles (UCNPs) are attracting much attention for their potential biological application, there are still several drawbacks that limit its general clinical use such as limited tissue penetration depth and sever overheating effect. Consequently, there has been extensive nanoparticle surface modification research into the design of improved alternative photosensitizers aimed at overcoming these drawbacks. Therefore, the goal of this project was to enhance the surface modification of UCNP to demonstrate high upconversion luminescence efficiency, as well as have hydrophilic surface characteristics that are compatible with biomolecule.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Maqsood, Zahra
• Tedla, Tamene Zewdu
• Chaudri, Asma

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-043015-063250

Advisor

• Reidinger, Zoe

Year

• 2015

Sponsor

• UMass Medical Center

Date created

• 2015-04-30

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright

Ultima modifica

• 2021-02-02