SFRP-1 (Secreted Frizzled Related Protein-1), an antagonist of the Wnt signaling pathway, has been implicated in the regulation of a wide variety of developmental signaling processes. The purpose of this project was to characterize the embryonic spatio-temporal expression of SFRP-1 during murine embryonic development. SFRP-1 is expressed in a number of different tissue and cell types, including cartilage (round proliferating chondrocytes) and bone (osteoblasts), suggesting that SFRP-1 may play an important role in the regulation of murine skeletal development.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Symons, John Gideon

Publisher

• Worcester Polytechnic Institute

Identifier

• 02D247M

Advisor

• Adams, David S.

Year

• 2002

Date created

• 2002-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright