In Vitro Skeletal Muscle Model with Mechanical StimulationPublic
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An in vitro skeletal muscle model can test treatment of myopathies and the efficacy of drugs; it allows for testing to be completed on human models without the need for patients, as well as limiting animal testing. When engineering skeletal muscle, the tissue must undergo conditioning biomimetic of its natural environment, such as mechanical strain. We developed an adjustable, uniaxial stimulation device. Tissue was transferred to the device and stimulated at 10% strain, demonstrating feasibility of the design.
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