In Vitro Skeletal Muscle Model with Mechanical Stimulation

Hickey, Kassondra Nicole; Almeida, Bethany Marie; Frankfort, Michelle Pham; Pizzini, James Eugene

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In Vitro Skeletal Muscle Model with Mechanical Stimulation

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An in vitro skeletal muscle model can test treatment of myopathies and the efficacy of drugs; it allows for testing to be completed on human models without the need for patients, as well as limiting animal testing. When engineering skeletal muscle, the tissue must undergo conditioning biomimetic of its natural environment, such as mechanical strain. We developed an adjustable, uniaxial stimulation device. Tissue was transferred to the device and stimulated at 10% strain, demonstrating feasibility of the design.

This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

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