Resveratrol and Cellular StressPublic
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When eukaryotes experience a stressor they produce stress granules due to the activation of the cellular stress response pathway via the phosphorylation of eIF2α. Utilizing acute exposure assays and fluorescent microscopy, stress granule formation was examined in cells that were treated with Resveratrol and other stilbene compounds. It was found that Resveratrol, Piceatannol, Oxyresveratrol, and Pinosylvin cause stress granule formation. Piceatannol was shown to be significantly less efficient in producing stress granules, while Pinosylvin exhibited significantly more stress granule formation.
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