A computational method known as the Similarity Ensemble Approach (SEA) was used to predict drug-target interactions for molecular scaffolds previously made in the Dittami lab. Through three different analyses of this SEA data, the most promising scaffolds were determined. These scaffolds will then be synthesized and the predictions will be validated through a biological assay.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Moussavi-Aghdam, Raha
• Lounsbury, Nicole A

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042711-155650

Advisor

• Dittami, James P.

Year

• 2011

Date created

• 2011-04-27

Resource type

• Major Qualifying Project

Major

• Chemistry

Rights statement

• In Copyright