Bone cell development can be studied using various cell lines in vitro. Analysis of a previously conducted microarray experiment showed a class of "neuronal" genes expressed in an early stage on bone development. These genes include ULIP, protease-nexin 1, and RAS p21 protein activator. They were observed to be expressed in successive stages of osteoblast development in C2C12, MC3T3, and MLO-Y4 cell lines using real-time quantitative PCR. The expression of these genes loosely correlated with changes in cell morphology.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Weiner, Brian Keith

Publisher

• Worcester Polytechnic Institute

Identifier

• 04D067M

Advisor

• Ryder, Elizabeth F.

Year

• 2004

Date created

• 2004-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright