Obesity is an increasing health problem across the United States, and green coffee bean extract (GCBE) may be a useful supplement to promote weight loss in humans; however, this supplement is anecdotal. GCBE has shown decreased fat accumulation in model organisms, and further studies in these systems help to elucidate the mechanism behind how green coffee bean extract is decreasing fat storage. Here, GCBE was supplemented in studies through high and low fat strains of C. elegans to observe pathways to determine whether this supplement is a viable option for tackling obesity. Through those pathways, the relationship between fat in the membrane and total fat content of the model organism will be more defined and ultimately aid in determining if GCBE is a safe and effective weight loss aid.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Reddington, Eveline D.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-051120-140708

Advisor

• Olsen, Carissa Lynn

Year

• 2020

Date created

• 2020-05-11

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright