Glioblastoma is a heterogeneous disease such that the receptors expressed vary based on tumor location. Working with Nemucore Medical Innovations, Inc., theranostic nanoemulsions were designed and manufactured to combat Glioblastoma and other brain diseases. Engineered targeting ligands incorporated in the nanoemulsions assisted in delivery to specific regions. Magnetic Resonance Imaging determined the bio-distribution in healthy rats across the Blood-Brain Barrier. Statistical analysis was completed with T1 MRI data for 174 defined regions. A 3-dimensional heat map program was created to integrate MRI imaging and statistical analysis. In conclusion, data demonstrates targeting ligands on the nanoemulsions alter pharmacodynamics in rat brains, shown by a fully integrated imaging system.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Burns, Tyler James
• Candiloro, Katie Marie
• Bora, Collette Madeline
• Stueber, Deanna Deakin

Colaboradores

• Patel, Niravkumar

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042616-124041

Advisor

• Lee, Kwonmoo

Year

• 2016

Sponsor

• Nemucore Medical Innovations

Date created

• 2016-04-26

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright