4D Maturation of Bioartificial Muscle for High Content Drug Screening Public
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Muscular dystrophies are a set of very serious muscular diseases that lack treatment as there are no animal models that accurately mimic the human 3D in vivo environment to provide accurate testing in clinical trials of various drugs and therapies. Therefore, our team designed and manufactured a customized cell culture lid for a 96-well plate that interfaces with a programmable Arduino stimulation system to promote muscle maturation. To test the electrical stimulation, bioartificial muscle (BAMs) were developed and stimulated under various regimens to measure the effect on tissue maturation and viability. Based on haemotoxylin and eosin histology stains, stimulated tissue constructs qualitatively showed improved myotube alignment and limited necrosis, compared to unstimulated tissue.
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