Student Work
A Pathogenesis Screen Using C. elegans to Identify Virulence Factors in C. albicans
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open in viewerFungal infections are a serious public health concern, especially in hospitalized immunocompromised patients, due to a dearth of antifungal agents. We aimed to study fungal pathogenesis and understand aspects of the host-pathogen interaction that makes Candida albicans a successful pathogen. Based on the observation that C. albicans is able to infect Caenorhabditis elegans, causing visible disease and ultimately death, we screened a library of C. albicans mutants for changes in virulence. We identified four novel genes that affected virulence: orf19.6713, orf19.1219, DOT4, and ZCF15.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-042810-104546
- Advisor
- Year
- 2010
- Date created
- 2010-04-28
- Resource type
- Major
- Rights statement
- 最新修改
- 2021-02-02
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- 属于 Collection:
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缩略图 | 标题 | 公开度 | Embargo Release Date | 行动 |
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A_Pathogenesis_Screen_Using_Caenorhabditis_elegans_to_Identify_Virulence_Factors_in_Candida_albicans.pdf | 公开 | 下载 |
Permanent link to this page: https://digital.wpi.edu/show/np193b883