Fungal infections are a serious public health concern, especially in hospitalized immunocompromised patients, due to a dearth of antifungal agents. We aimed to study fungal pathogenesis and understand aspects of the host-pathogen interaction that makes Candida albicans a successful pathogen. Based on the observation that C. albicans is able to infect Caenorhabditis elegans, causing visible disease and ultimately death, we screened a library of C. albicans mutants for changes in virulence. We identified four novel genes that affected virulence: orf19.6713, orf19.1219, DOT4, and ZCF15.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Pastor, Kelly Anne
• Chiasson, Margaret Anne
• Landry, Benjamin David
• McCannell, Kurtis Neil

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042810-104546

Advisor

• Rao, Reeta Prusty

Year

• 2010

Date created

• 2010-04-28

Resource type

• Major Qualifying Project

Major

• Biochemistry
• Biology & Biotechnology

Rights statement

• In Copyright

Última modificação

• 2021-02-02