Student Work

A Pathogenesis Screen Using C. elegans to Identify Virulence Factors in C. albicans

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Fungal infections are a serious public health concern, especially in hospitalized immunocompromised patients, due to a dearth of antifungal agents. We aimed to study fungal pathogenesis and understand aspects of the host-pathogen interaction that makes Candida albicans a successful pathogen. Based on the observation that C. albicans is able to infect Caenorhabditis elegans, causing visible disease and ultimately death, we screened a library of C. albicans mutants for changes in virulence. We identified four novel genes that affected virulence: orf19.6713, orf19.1219, DOT4, and ZCF15.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
Creator
Publisher
Identifier
  • E-project-042810-104546
Advisor
Year
  • 2010
Date created
  • 2010-04-28
Resource type
Major
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Última modificação
  • 2021-02-02

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