Student Work

 

A Pathogenesis Screen Using C. elegans to Identify Virulence Factors in C. albicans Public

Downloadable Content

open in viewer

Fungal infections are a serious public health concern, especially in hospitalized immunocompromised patients, due to a dearth of antifungal agents. We aimed to study fungal pathogenesis and understand aspects of the host-pathogen interaction that makes Candida albicans a successful pathogen. Based on the observation that C. albicans is able to infect Caenorhabditis elegans, causing visible disease and ultimately death, we screened a library of C. albicans mutants for changes in virulence. We identified four novel genes that affected virulence: orf19.6713, orf19.1219, DOT4, and ZCF15.

Last modified
  • 02/02/2021
Creator
Publisher
Identifier
  • E-project-042810-104546
Advisor
Year
  • 2010
Date created
  • 2010-04-28
Resource type
Major
Rights statement
License

Relationships

In Collection:

Items

Permanent link to this page: https://digital.wpi.edu/show/np193b883