. . . "Worcester Polytechnic Institute" . . "2010" . "2021-02-02T09:56:55.339263647-05:00"^^ . "http://rightsstatements.org/vocab/InC/1.0/" . "This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review." . . "Rao, Reeta Prusty" . "StudentWork" . "2020-01-17T07:21:10.477911573-05:00"^^ . "E-project-042810-104546" . "depositor@wpi.edu" . . "2010-04-28" . "Pastor, Kelly Anne" . "Chiasson, Margaret Anne" . "Landry, Benjamin David" . "McCannell, Kurtis Neil" . . "A Pathogenesis Screen Using C. elegans to Identify Virulence Factors in C. albicans" . "Major Qualifying Project" . "Biochemistry" . "Biology & Biotechnology" . . "Fungal infections are a serious public health concern, especially in hospitalized immunocompromised patients, due to a dearth of antifungal agents. We aimed to study fungal pathogenesis and understand aspects of the host-pathogen interaction that makes Candida albicans a successful pathogen. Based on the observation that C. albicans is able to infect Caenorhabditis elegans, causing visible disease and ultimately death, we screened a library of C. albicans mutants for changes in virulence. We identified four novel genes that affected virulence: orf19.6713, orf19.1219, DOT4, and ZCF15." . . "ActiveFedora::Aggregation::ListSource" . . . . .