The most daunting obstacle in the treatment of Glioblastoma Multiforme (GBM) lies with the impenetrability of the Blood Brain Barrier. This project aimed to design and engineer nanomedicines that have the aptitude to overcome this complication. The method of manufacturing the nanomedicines allowed for a variety of chemotherapeutics to be encapsulated. Once the nanomedicines were proven to be stable, cytotoxicity assays were conducted. GBM specific drugs were not as effective as broad-spectrum chemotherapeutics, even when combined with known pro-apoptotic factors.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Cacaccio, Joseph
• Wrabel, Eileen Susan

Contributors

• Coleman, Timothy P.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-043014-162827

Advisor

• Heilman, Destin

Year

• 2014

Sponsor

• Nemucore Medical Inovations

Date created

• 2014-04-30

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright