Understanding the mechanisms involved in DNA repair is an important step in understanding and possibly controlling numerous human diseases.  Previously the S. cerevisiae gene SUB1 and its human ortholog PC4 have been shown to play an important role in the repair of DNA lesions resulting from oxidative stress. In this project I use a novel TRP5 reversion system to study the mutational changes in sub1 deletion strains. Canavanine mutagenesis was also utilized to test spontaneous mutation frequency.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Pope, Patricia Anne

Colaboradores

• Volkert, Michael

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042306-142647

Advisor

• Adams, David S.

Year

• 2016

Sponsor

• University of Massachusetts Medical Center

Date created

• 2016-10-07

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright