The Epidermal Growth Factor Receptor (EGFR) family of tyrosine kinases play a key role in development and cancer. Kek1, a transmembrane protein, has been previously shown to inhibit the EGFR in Drosophila through its extracellular Domain V. To define structural elements of Domain V that mediate Kek1 binding, a phylogenetic analysis was carried out on Domain V, and five Domain V variants were designed to be tested for their ability to interact with Kek1.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Johnson, Caroline M.

Publisher

• Worcester Polytechnic Institute

Identifier

• 23226
• E-project-050621-160704

Award

• Provost's MQP Award

Advisor

• Gericke, Arne
• Duffy, Joseph B.

Year

• 2021

Date created

• 2021-05-06

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright

Last modified

• 2023-01-19