As pharmaceutical spending increases, the need for predictive disease models is ever rising. Tissue-engineered skeletal muscle (TESM) could offer functional units of human skeletal muscle tissue for high-throughput drug screening and may circumnavigate the non-predictive nature of most traditional preclinical model systems for musculoskeletal diseases. However, current TESM constructs are immature and lack biomimicry to native tissue. Tissue maturation strategies such as mechanical and electrical stimulation have been employed in an effort to improve biomimicry, and have been demonstrated to improve myofiber alignment, protein expression, and contractile ability. In this MQP, a device was designed to mechanically and electrically stimulate TESM constructs in a high-throughput manner.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Goncalves, Annabella Perolino
• Cossette, Benjamin James
• Marry, Alexander Keith
• William, Mina Essam

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042617-142945

Advisor

• Page, Raymond L.

Year

• 2017

Date created

• 2017-04-26

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright