A better understanding of mechanisms that regulate cellular lifespan is needed to exploit the balance between senescence in normal cells and uncontrolled proliferation in cancer cells. We show that low oxygen and supplementation with FGF2 significantly extends cellular lifespan. Cells decrease expression of tumor suppressor p53 and p53 is downregulated further in late-passage cells. Lower levels of p53 protein accompany lower levels of transcription.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Shumaker, Lucia R.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-043015-053401

Advisor

• Dominko, Tanja

Year

• 2015

Date created

• 2015-04-30

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright