Role of p53 in Extending Longevity in Untransformed Fibroblasts Public
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A better understanding of mechanisms that regulate cellular lifespan is needed to exploit the balance between senescence in normal cells and uncontrolled proliferation in cancer cells. We show that low oxygen and supplementation with FGF2 significantly extends cellular lifespan. Cells decrease expression of tumor suppressor p53 and p53 is downregulated further in late-passage cells. Lower levels of p53 protein accompany lower levels of transcription.
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