Student Work

 

Perfused Tumor-Tissue Model for ​In Vitro ​Invasion Analysis Public

Downloadable Content

Download PDF

Cancer is the 9th leading cause of death globally. Cancer is challenging to treat due to metastasis, which starts as tumor cell invasion from the primary tumor into the surrounding tissue. There is an increased need for physiologically relevant models of tumor cell invasion to improve understanding of cancer progression. This project constructed a perfusion bioreactor that supported an in vitro model of cell invasion that can be imaged and evaluated using light microscopy. This design incorporated a syringe pump connected to three individual well units that could be perfused simultaneously. The bioreactor was tested for proof of concept using materials and flow rates representative of the tumor microenvironment, and a MATLAB® program was developed to analyze cell images.

Creator
Publisher
Identifier
  • E-project-051420-160343
Advisor
Year
  • 2020
Date created
  • 2020-05-14
Resource type
Major
Rights statement
License

Relationships

In Collection:

Items

Permanent link to this page: https://digital.wpi.edu/show/kd17cw410