The goal of this project was to develop a scaffold with an extracellular matrix composition that enhances epidermal cell adhesion by mimicking the basal lamina in native human skin. A high-throughput method was developed which facilitates surface conjugation of basal lamina components (fibronectin, laminin, and collagen) to a collagen-glycosaminoglycan membrane and allows for multiple isolated experiments performed in parallel. The findings of these studies will aid in the design of the "off-the-shelf" skin substitutes with optimal surface composition for epidermal regeneration.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Tressel, Sarah Lynne
• Coughlan, Kristin Anne

Publisher

• Worcester Polytechnic Institute

Identifier

• 03D050M

Advisor

• Pins, George D
• Billiar, Kristen

Year

• 2003

Date created

• 2003-01-01

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright