Student Work
Acenaphthene analogs as K-C1 cotransport activators
PubblicoThe K-C1 cotransport system controls potassium and chloride ion flux across erythrocyte cell membranes. It was previously determined that K-C1 cotransport activation requires the presence of a naphthylene ring in the activating drug. Therefore, this project's purpose was to test the effects of 1,8-naphthylene ring substitutions on flux activation. Acenaphthene and acenaphthylene exhibited the greatest amount of potassium flux; 1-substituted analogs induced moderate flux in the presence of calcium, while other analogs showed no effect. Consequently, a revised binding site model is proposed.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- 01D237M
- Advisor
- Year
- 2001
- Date created
- 2001-01-01
- Resource type
- Major
- Rights statement
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