The K-C1 cotransport system controls potassium and chloride ion flux across erythrocyte cell membranes. It was previously determined that K-C1 cotransport activation requires the presence of a naphthylene ring in the activating drug. Therefore, this project's purpose was to test the effects of 1,8-naphthylene ring substitutions on flux activation. Acenaphthene and acenaphthylene exhibited the greatest amount of potassium flux; 1-substituted analogs induced moderate flux in the presence of calcium, while other analogs showed no effect. Consequently, a revised binding site model is proposed.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Skarin, Diane L.
• McCusker, Heather
• Ricci, Nicole C.

Publisher

• Worcester Polytechnic Institute

Identifier

• 01D237M

Advisor

• Hobey, William D.

Year

• 2001

Date created

• 2001-01-01

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright