The human gene Suppression of Tumorigenicity-18 (ST-18) encodes a zinc finger protein previously associated with breast carcinoma, however it may have an oncogenic role in the development of Inversion 16 leukemia (inv16). This project assayed the level of ST-18 in inv16 leukemic lines compared to unrelated cancer lines. The data show that ST-18 is more highly expressed in an inv16 acute myeloid leukemic cell line (Me-1) compared to Kasumi-1 and U937 non-inv16 cancer lines. In addition, murine ST-18 was successfully cloned into plasmid vector pMSCV2.2 for use in future over-expression experiments.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Peterson, Dana Alexandra

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042811-144243

Advisor

• Adams, David S.

Year

• 2011

Sponsor

• UMass Medical Center

Date created

• 2011-04-28

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright