The prevalence of Alzheimers Disease (AD) is rising worldwide. Characterized by accumulation of amyloid-beta plaques in the brain, AD results in loss of cognitive and motor functions, with a theorized link to metabolism and ATP production. This study used transgenic AD-model and metabolic mutant Caenorhabditis elegans to investigate punicalagin and coenzyme Q10 treatments through behavioral and ATP-quantifying assays. Both treatments were successful in rescuing chemosensation in AD and metabolic mutant strains, suggesting a metabolic deficiency that results in olfactory dysfunction.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• McNeill, Nathan
• Randle, Lily Jane
• Consedine, Timothy Edward

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042518-205706

Advisor

• Olsen, Carissa Lynn
• Srinivasan, Jagan

Year

• 2018

Date created

• 2018-04-25

Resource type

• Major Qualifying Project

Major

• Biochemistry
• Biology & Biotechnology

Rights statement

• In Copyright