Student Work
Investigating the Role of Multimerization in human Torque Teno Virus VP3 Cancer Cell Specific Apoptosis
PublicThe human Torque Teno Virus Viral Protein 3 (TTV VP3) has been shown to induce apoptosis in cancer cell lines via a p53-independent pathway similar to its homolog Apoptin, demonstrating its potential as a cancer therapeutic. Apoptin forms aggregates in the nucleus while TTV VP3 localizes in the cytoplasm. In order to determine whether TTV VP3 forms multimers like Apoptin and if multimerization is essential for apoptosis induction, GFP and FLAG-tagged VP3 constructs were created and transfected into the lung cancer H1299 cell line and analyzed for TTV VP3 protein interaction by co-immunoprecipitation studies.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-043014-182945
- Advisor
- Year
- 2014
- Date created
- 2014-04-30
- Resource type
- Major
- Rights statement
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TTVVP3_Multimerization_MQP.pdf | Public | Download |
Permanent link to this page: https://digital.wpi.edu/show/jh343t77j