Phytoestrogens are popular substances used in hormone replacement therapy due to their similar structure to estrogen and ability to interact like estrogens in the body. One particular phytoestrogen compound, genistein, has been observed to have an antiproliferative effect on breast cancer cells. The experiments investigated the effects of estrogen and genistein on the cells through MTS assays and PCNA immunoblots. The cell line demonstrated estrogen responsiveness through both assays, but results as to genistein's effect on the T47D breast epithelial cells were inconclusive.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Ferrari, Christina Marie
• Akhtar, Mohammed Suhail

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042910-133829

Advisor

• Buckholt, Michael Allan
• Rulfs, Jill

Year

• 2010

Date created

• 2010-04-29

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright