A lactate biosensor was designed to monitor tumor size in patients with Glioblastoma Multiforme, an aggressive form of brain tumor. Current monitoring methods are expensive and not conducive to frequent use, creating a need for a biosensor to frequently monitor GBM tumor size. This biosensor was composed of polypyrrole (PPY) and polyaniline (PANI) layers with lactate oxidase (LOX) cross-linked to the surface using glutaraldehyde. The components of the biosensor were tested iteratively. The biosensor is able to detect increases in lactate concentration. It is has a higher maximum current than other designs and is able to detect greater presence of lactate. More testing is needed in order to continue validation of the biosensor and extend the technology to other metabolites.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Jones, Emily Kathryn

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-043014-221333

Advisor

• Jain, Anjana
• Zhou, H Susan

Year

• 2014

Date created

• 2014-04-30

Resource type

• Major Qualifying Project

Major

• Interdisciplinary

Rights statement

• In Copyright

Last modified

• 2020-12-27