Student Work
An Engineered Receptor Coupled With a Small Molecule System Activates a Stress Signaling Pathway Critical to the ERAD Response
ÖffentlichEndoplasmic reticulum (ER) stress is caused by the accumulation of misfolded proteins in the ER. IRE1, an ER localized transmembrane protein kinase, is a sensor of unfolded proteins and plays an important role in regulating the cellular rescue response to ER stress. We have engineered FV2E-IRE1a, a drug controlled receptor that exploits the IRE1 cell rescue pathway. Addition of the drug AP20187 induces stress-uncoupled activation of FV2E IRE1 and causes IRE1 signaling. Our results indicate that the use of this system has utility in regulating the cytoprotective IRE1-ERAD pathway independently of other ER stress-induced signals, such as proapototic JNK signaling.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-042605-010126
- Advisor
- Year
- 2005
- Sponsor
- Date created
- 2005-04-26
- Resource type
- Major
- Rights statement
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