Structure and Function Characterization of Kekkon 3 in Drosophila
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open in viewerThe Kekkon family in Drosophila belongs to a class of transmembrane LIG proteins that contains both leucine-rich repeats (LRRs) and an immunoglobulin (Ig) domain in the extracellular domain. Two family members, Kek 1 and Kek 5, have been shown to inhibit the Drosophila EGFR receptor (DER) and Bone Morphogenetic Protein (BMP) signaling, respectively. Prior work on a related family member, Kek3, also suggested a role in BMP signaling. To further investigate this, structural/functional analyses of Kek3, was undertaken. Phylogenetic analysis was used to identify highly conserved regions of Kek3, and in addition to the LRRs and Ig domain, revealed a set of conserved intracellular motifs of unknown function. A variant of Kek3 lacking the intracellular domain was created for functional studies.
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- Creator
- Contributors
- Publisher
- Identifier
- E-project-043015-131714
- Advisor
- Year
- 2015
- Date created
- 2015-04-30
- Resource type
- Major
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