Surface Derivatization of Glucan Particles for Drug Delivery
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open in viewerGlucan particles (GPs) are hollow, porous 2-4 micron microspheres derived from the cell walls of Bakers yeast. The glucan content on the surface of the particles allows for receptor mediated cell uptake by cells with beta-glucan receptors. GPs have been used for the delivery of macromolecules encapsulated inside the hollow GPs via layer-by-layer synthesis. In this project, the outer surface of GPs was chemically derivatized to introduce different charged functional groups. The modified GPs were evaluated for charged nanoparticle (aminated latex and carboxylated polystyrene) and soluble payload (i.e. siRNA, doxorubicin) surface binding and for efficient GP-mediated payload delivery to a model murine GP phagocytic cell line (NIH 3T3-D1).
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-042511-124623
- Advisor
- Year
- 2011
- Sponsor
- Date created
- 2011-04-25
- Resource type
- Major
- Rights statement
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- In Collection:
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Miniaturansicht | Titel | Sichtbarkeit | Embargo Release Date | Aktionen |
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Castle_MQP_Revised.pdf | Öffentlich | Herunterladen |
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