This study involves the analysis of over-the-counter phytoestrogen supplements due to their anti-proliferative effects on breast cancer cells. Phytoestrogens have been used as alternatives to traditional hormone therapy in postmenopausal women. TLC and HPLC were employed to optimize extraction and separation of these compounds from over-the-counter supplements. Testing of Promensil, Black Cohosh, and Soy Isoflavone supplements revealed that significant anti-proliferative effects observed in Promensil and Black Cohosh may be attributable to their combination of the phytoestrogens daidzein and biochanin A.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Grinnell, Graham Nelson

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-062013-114450

Advisor

• Buckholt, Michael Allan
• Rulfs, Jill

Year

• 2013

Date created

• 2013-06-20

luogo

• Worcester

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright