The effects of the anti-inflammatory, non-psychoactive cannabinoid-ajulemic acid (AjA)-were studied in cultured synoviocytes from arthritis patients. Cells were divided among treatments including untreated controls, AjA-treated, and prostaglandin J treated groups and were unstimulated or stimulated with TNF-a. Three gene arrays were used to access the expression of genes of inflammation and immunity in the NFkB pathway. Treatment with AjA significantly affected the expression of many genes-including IL-1, in the synoviocytes. Prostaglandin J did not show similar effects.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Skulas, Ann Christine

Publisher

• Worcester Polytechnic Institute

Identifier

• 05D272M

Advisor

• Rulfs, Jill

Year

• 2005

Date created

• 2005-01-01

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright