Student Work
Regulation of gene expression by ajulemic acid
ÖffentlichThe effects of the anti-inflammatory, non-psychoactive cannabinoid-ajulemic acid (AjA)-were studied in cultured synoviocytes from arthritis patients. Cells were divided among treatments including untreated controls, AjA-treated, and prostaglandin J treated groups and were unstimulated or stimulated with TNF-a. Three gene arrays were used to access the expression of genes of inflammation and immunity in the NFkB pathway. Treatment with AjA significantly affected the expression of many genes-including IL-1, in the synoviocytes. Prostaglandin J did not show similar effects.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- 05D272M
- Advisor
- Year
- 2005
- Date created
- 2005-01-01
- Resource type
- Major
- Rights statement
Beziehungen
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Objekte
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