Candida albicans is a part of the gut microbiome. Overgrowth of C. albicans is associated with Crohn's Disease and Colitis. Beneficial gut microbes keep C. albicans from overgrowth. We use the model host nematode Caenorhabditis elegans to elucidate the interactions between pathogenic and beneficial gut microbes. We have identified C. albicans mutants that exhibit differential interaction with the beneficial bacteria B. subtilis to alter host lifespan. Further analysis of these genes will identify pathways that modulate microbial interactions to alter host outcomes.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Awada, Rosemarie D.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-050321-140145
• 21461

Advisor

• Rao, Reeta Prusty

Year

• 2021

Date created

• 2021-05-03

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright