Primary cilia are specialized signaling organelles that play key roles during development and in adult tissues. The ciliary proteome comprises roughly 1000 proteins; however, the molecular functions of most ciliary proteins remain unknown. This project uses the nematode C. elegans as a model system to characterize the roles of two putative ciliary genes asic-2 and xbx-6 in neuronal cilia formation. Using genetics and high-resolution microscopy, we describe xbx-6 expression pattern and characterize cilia morphology in AWA neurons in asic-2(ok289) mutants.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Beigi, Nazanin
• Ferrero, Domenica G.

Publisher

• Worcester Polytechnic Institute

Identifier

• 22976
• E-project-050621-132644

Advisor

• Nechipurenko, Inna

Year

• 2021

Date created

• 2021-05-06

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright