Brain tumors, such as glioblastoma multiforme, have extraordinarily low five-year survival rates. Currently, it is difficult to monitor in real-time the progression of a tumor and how it responds to therapy. Biosensors been used to measure key metabolites, such as lactate and glutamate, at shorter time intervals to detect abnormal blood levels. In this study, an enzymatic coating to detect lactate was developed in vitro. Chitosan was used to immobilize lactate enzyme. The chitosan with the enzyme was coated a glassy carbon electrode and tested at different concentrations of aqueous lactic acid as a proof of concept.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Sokoloff, Brian James
• Doolin, Clare Ellen
• Scrivanich, Nicholas John

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042816-143827

Advisor

• Zhou, H Susan
• Jain, Anjana

Year

• 2016

Date created

• 2016-04-28

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright

Dernière modification

• 2020-12-27