Student Work
Synthesis of New Pharmacophore Scaffolds
PublicDownloadable Content
open in viewerThe photo-initiated cyclization of aryl-vinyl ethers has been shown to create multicyclic natural product-like scaffolds with predicted biological activity. Utilizing this method, one can construct up to three fused rings and six chiral centers in a single experimental operation. A chemo-informatics analysis of these structures has identified scaffolds which are likely to interact with proteins. Using these predictions, our group has constructed two scaffolds with predicted biological activity.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-042413-153148
- Advisor
- Year
- 2013
- Date created
- 2013-04-24
- Resource type
- Major
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Thumbnail | Title | Visibility | Embargo Release Date | Actions |
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Synthesis_of_New_Pharmacophore_Scaffolds.pdf | Public | Download |
Permanent link to this page: https://digital.wpi.edu/show/f4752j187