The photo-initiated cyclization of aryl-vinyl ethers has been shown to create multicyclic natural product-like scaffolds with predicted biological activity. Utilizing this method, one can construct up to three fused rings and six chiral centers in a single experimental operation. A chemo-informatics analysis of these structures has identified scaffolds which are likely to interact with proteins. Using these predictions, our group has constructed two scaffolds with predicted biological activity.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Domingue, Emily Carol
• Fusco, Matthew Pieter

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042413-153148

Advisor

• Dittami, James P.

Year

• 2013

Date created

• 2013-04-24

Resource type

• Major Qualifying Project

Major

• Chemistry

Rights statement

• In Copyright