Employing Template-Directed Assembly to Create a Novel Coagulation AssayPublic
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Blood coagulation is an important aspect of hemostasis in the human body. Under normal circumstances, the blood coagulates using two different pathways, the intrinsic and the extrinsic. The extrinsic pathway works to counteract trauma but may lead to stroke forming clots. Components for an assay were created so that an assay could be designed to test the functionality of the proteins involved in the clotting cascade: Tissue Factor, factor VII, and factor X when used in conjunction with Template Directed Assembly (TDA) on a nickel-nitriloacetic acid (Ni-NTA) derived liposome.
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