Student Work
The Role of SUB1 in the Repair of UV Induced DNA Damage in Saccharomyces cerevisiae
PúblicoUnderstanding the mechanisms involved in DNA repair is an important step in understanding and possibly controlling numerous human diseases. Previously the S. cerevisiae gene SUB1 and its human ortholog PC4 have been shown to play an important role in the repair of DNA lesions resulting from oxidative stress. In this project, I demonstrate that sub1 deletion mutants do not show an increase in UV sensitivity, however, in strains with combinations of other repair genes knocked out, the addition of the sub1 deletion does result in increased UV sensitivity.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-042306-143701
- Advisor
- Year
- 2006
- Sponsor
- Date created
- 2006-04-23
- Resource type
- Major
- Rights statement
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