The objective of this project was to determine if the antioxidant, -lipoic acid (LA), inhibits oxalate (OX) toxicity, via free radical production, on renal systems. The cell line, LLC-PK, was used as a model to observe this phenomenon in kidney cells. LA was found to have no effect preventing OX-induced damage at the dosages tested. The implications of this study should encourage further studies of novel drugs which may have the property of reducing oxidative damage to renal systems.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Hwang, John S.

Publisher

• Worcester Polytechnic Institute

Identifier

• 00D140M

Advisor

• Adams, David S.

Year

• 2000

Sponsor

• UMass Medical School

Date created

• 2000-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright