RNA interference (RNAi) is a sequence-specific silencing phenomenon that is conserved in animals, plants and some bacteria (Fire and Mello, 1998; Meister and Tuschl, 2004). At least 4 different AGO pathways are thought to function in the germline of C. elegans. In an effort to understand how these pathways remain independent from one another, we are using yeast two-hybrid to identify proteins that interact with and potentially regulate AGOs. The results showed colonies which grew on secondary selection plates indicated potential interacting proteins for the argonautes of interest.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Nwagbara, Belinda Uchechi

贡献者

• Mello, Craig

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042513-112907

Advisor

• Heilman, Destin

Year

• 2013

Sponsor

• UMass Medical School

Date created

• 2013-04-25

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

最新修改

• 2023-09-19