Recent advances in whole transcriptome sequencing have revealed that the majority of the genome is transcribed but only 1% of transcripts are coded for protein biosynthesis. This remaining "˜junk DNA' includes non-coding RNA species (ncRNA), which have been implicated in modulating tumorigenesis as well as tumor suppression if they are misexpressed. Recent experiments indicate that loss of the Retinoblastoma tumor suppressor protein (pRB), a transcriptional co-regulator, alters the expression of both coding and non-coding transcripts. This project seeks to understand if misexpression of these ncRNAs plays a role in the pleiotropic effects of pRB loss in cancer.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Sadiq, Hammad M.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042519-131603

Award

• Provost's MQP Award

Advisor

• Manning, Amity L.

Year

• 2019

Date created

• 2019-04-25

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

Última modificação

• 2023-01-19