This project examined the transcriptional regulation of the 2A adrenergic receptors in a central adrenergic cell line (CATH.a). The study suggests that cAMP induces the transcription of 2A gene in these cells. It is also consistent with the fact that the cAMP response element binding protein (CREB) is not involved in the basal transcription of the 2A gene. These results suggest the presence of a different basal transcription mechanism than the one used in other studied cell lines (RIN5mF).

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Felekkis, Kyriacos Nicos

Publisher

• Worcester Polytechnic Institute

Identifier

• 00C010M

Advisor

• Ryder, Elizabeth F.

Year

• 2000

Sponsor

• Boston University Medical School

Date created

• 2000-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright