Rescue of a nonfunctional Newcastle disease hemagglutinin-neuraminidase protein by mutation of key residues residing at the dimer interface

Quinlan, Edward James

Student Work

Rescue of a nonfunctional Newcastle disease hemagglutinin-neuraminidase protein by mutation of key residues residing at the dimer interface

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Newcastle disease virus (NDV) is an avian pathogen that is capable of devastating localized livestock populations in a matter of weeks. When hemagglutinin-neuraminidase (HN) I175 is mutated to a glutamic acid in the Australia-Victoria (AV) isolate, all HN function is lost, however this loss of function is not seen in the L-Kansas (L) isolate. Through mutation of chimeric HN proteins we have identified four amino acids that together, rescue function of I175E AV HN.

This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

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