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Novel Epidermal Growth Factor Receptor Drug Platforms

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Aberrant signaling by the epidermal growth factor receptor (ErbB) family plays a central role in tumor development and is a target for pharmacological intervention. A major challenge in drug discovery is the evaluation of new compounds at the organismal level. Due to conservation of the ErbB network between Drosophila and humans, flies offer an attractive system for this. I have generated transgenic Drosophila with human ErbB receptors and used them to develop an in vivo assay to screen for therapeutics.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042811-140640
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  • 2011
Date created
  • 2011-04-28
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