Artemisia annua and Artemisia afra are cost-effective antimalarial drugs, therefore, it is necessary to understand the possible lasting genetic effects they could have on a patient and their children via testing. One test is the mutagenicity assay, also called the Ames test. This is done by using genetically modified Salmonella typhimurium strains to determine if the test sample can restore the gene function of the modified strain through mutation, allowing the bacteria to grow. Colonies are counted and compared to negative controls to suggest the sample’s mutagenicity. In this assay for A. annua and A. afra, it was anticipated that the Ames test would validate that the plant extracts are non-mutagenic and these results implied non-mutagenicity.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Marquez, Jessica M.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-070820-201109

Advisor

• Weathers, Pamela
• Gericke, Arne

Year

• 2020

Date created

• 2020-07-08

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright